Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation-Reference-Cited by-同舟云学术

Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation

Published:2010-01-15 Issue:5963 Volume:327 Page:331-334
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Alvarez Hamsell M.¹,Xue Yi¹,Robinson Chandler D.¹,Canalizo-Hernández Mónica A.¹,Marvin Rebecca G.¹,Kelly Rebekah A.²,Mondragón Alfonso³,Penner-Hahn James E.²,O’Halloran Thomas V.¹³

Affiliation:

1. The Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA.

2. Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA.

3. Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.

Abstract

Targeting Copper Clusters Tetrathiomolybdate (TM) is a copper-depleting agent that has potential in treating copper-dependent diseases. Alvarez et al. (p. 331 , published online 26 November) used spectroscopic and structural studies to show that TM inhibits the yeast copper chaperone Atx1 by forming a TM-Cu-ATx1 complex that is stabilized by a sulfur-bridged copper-molybdenum cluster. Cluster formation prevents transfer of copper from the chaperone to target enzymes. The results provide a basis for developing drugs that target metallation pathways.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. Action of Molybdenum in Nutrition of Milking Cattle

2. Demyelination in Lambs Born of Ewes Maintained on High Intakes of Sulphate and Molybdate

3. Copper Control as an Antiangiogenic Anticancer Therapy: Lessons from Treating Wilson's Disease

4. J. M. Walshe in Orphan Diseases and Orphan Drugs I. H. Scheinberg J. M. Walshe Eds. (Manchester Univ. Press Manchester UK 1986) pp. 76–85.

5. Initial Therapy of Patients With Wilson's Disease With Tetrathiomolybdate

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