Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus-Reference-Cited by-同舟云学术

Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus

Published:2016-05-27 Issue:6289 Volume:352 Page:1105-1109
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ghssein Ghassan¹²³,Brutesco Catherine¹²³,Ouerdane Laurent⁴,Fojcik Clémentine⁵,Izaute Amélie¹²³,Wang Shuanglong⁴,Hajjar Christine¹²³,Lobinski Ryszard⁴,Lemaire David²³⁶,Richaud Pierre²³⁷,Voulhoux Romé⁸,Espaillat Akbar⁹,Cava Felipe⁹,Pignol David¹²³,Borezée-Durant Elise⁵,Arnoux Pascal¹²³

Affiliation:

1. Laboratoire de Bioénergétique Cellulaire, Institut de Biosciences et Biotechnology Aix-Marseille (BIAM), Commissariat à l‘Energie Atomique et aux Energies Alternatives (CEA), 13108 Saint-Paul-lès-Durance, France.

2. UMR 7265, Centre National de Recherche Scientifique, Saint-Paul-lès-Durance, France.

3. Aix Marseille Université, Marseille, France.

4. Université de Pau et des Pays de l‘Adour/CNRS, Laboratoire de Chimie Analytique Bio-inorganique et Environnement, IPREM-UMR5254, Hélioparc, 2, Avenue Angot, 64053 Pau, France.

5. Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.

6. Lab Interact Protein Metal, BIAM, CEA, 13108 Saint-Paul-lès-Durance, France.

7. Lab Bioenerget Biotechnol Bacteries et Microalgues, BIAM, CEA, 13108 Saint-Paul-lès-Durance, France.

8. CNRS et Aix-Marseille Université, Laboratoire d’Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée, Marseille, France.

9. Laboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.

Abstract

A new metal scavenger for bacteria All cells must find a way to acquire trace metals. Bacteria and plants scavenge iron, for instance, by synthesizing and releasing iron-chelating compounds called siderophores. Ghssein et al. describe three enzymes in Staphylococcus aureus that are responsible for the biosynthesis of another type of metallophore (see the Perspective by Nolan). Metabolomics and a range of biochemical assays show that this compound, named staphylopine, is involved in the uptake of a range of metals, depending on the growth environment. The genes required for staphylopine biosynthesis are conserved across a number of pathogenic bacteria and are similar to those for a broad-spectrum metallophore produced by plants. Science , this issue p. 1105 ; see also p. 1055

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference48 articles.

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