Lassa virus entry requires a trigger-induced receptor switch

Author:

Jae Lucas T.1,Raaben Matthijs12,Herbert Andrew S.3,Kuehne Ana I.3,Wirchnianski Ariel S.3,Soh Timothy K.2,Stubbs Sarah H.2,Janssen Hans1,Damme Markus4,Saftig Paul4,Whelan Sean P.2,Dye John M.3,Brummelkamp Thijn R.156

Affiliation:

1. Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.

2. Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

3. U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702–5011, USA.

4. Biochemisches Institut, Christian Albrechts-Universität Kiel, 24118 Kiel, Germany.

5. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

6. Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.

Abstract

How Lassa virus breaks and enters Lassa virus, which spreads from rodents to humans, infecting about half a million people every year, can lead to deadly hemorrhagic fever. Like many viruses, Lassa virus binds to cell surface receptors. Jae et al. now show that to enter a cell, the virus requires a second receptor, this one inside the infected cell. This requirement sheds light on the “enigmatic resistance” of bird cells to Lassa virus observed three decades ago. Although bird cells have the cell surface receptor, the intracellular receptor cannot bind the virus, stopping it in its tracks. Science , this issue p. 1506

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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