Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry-Reference-Cited by-同舟云学术

Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry

Published:2013-04-26 Issue:6131 Volume:340 Page:479-483
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jae Lucas T.¹,Raaben Matthijs²,Riemersma Moniek³⁴⁵,van Beusekom Ellen⁵,Blomen Vincent A.¹,Velds Arno¹,Kerkhoven Ron. M.¹,Carette Jan E.⁶,Topaloglu Haluk⁷,Meinecke Peter⁸,Wessels Marja W.⁹,Lefeber Dirk J.³⁴,Whelan Sean P.²,van Bokhoven Hans⁵,Brummelkamp Thijn R.¹¹⁰

Affiliation:

1. Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

2. Department of Microbiology and Immunobiology, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Neurology, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, 6525 GA Nijmegen, Netherlands.

4. Laboratory of Genetic, Endocrine and Metabolic Disease, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, 6525 GA Nijmegen, Netherlands.

5. Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Post Office Box 9101, 6500 HB Nijmegen, Netherlands.

6. Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA.

7. Hacettepe University Children’s Hospital, 06100 Ankara, Turkey.

8. Institut für Humangenetik, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg, Germany.

9. Department of Clinical Genetics, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands.

10. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

Abstract

Viruses and Congenital Disorders Mutations in genes involved in α-dystroglycan O-linked glycosylation result in posttranslation modifications associated with the congenital disease Walker-Warburg syndrome (WWS). This cellular modification is also required for efficient Lassa virus infection of cells. Jae et al. (p. 479 , published online 21 March) screened for genes involved in O-glycosylation that affected Lassa virus infection and identified candidates involved in glycosylation. Individuals from different pedigrees exhibiting WWS had unique mutations among genes identified in the genetic screen. Thus, comprehensive forward genetic screens can be used to define the genetic architecture of a complex disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. O -Mannosyl Phosphorylation of Alpha-Dystroglycan Is Required for Laminin Binding

2. Dystroglycanopathies: coming into focus

3. Post-translational disruption of dystroglycan–ligand interactions in congenital muscular dystrophies

4. Role of α-Dystroglycan as a Schwann Cell Receptor for Mycobacterium leprae

5. Identification of α-Dystroglycan as a Receptor for Lymphocytic Choriomeningitis Virus and Lassa Fever Virus

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