A Fine-Scale Chimpanzee Genetic Map from Population Sequencing-Reference-Cited by-同舟云学术

A Fine-Scale Chimpanzee Genetic Map from Population Sequencing

Published:2012-04-13 Issue:6078 Volume:336 Page:193-198
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Auton Adam¹²,Fledel-Alon Adi³,Pfeifer Susanne⁴,Venn Oliver¹,Ségurel Laure³⁵,Street Teresa⁴,Leffler Ellen M.³,Bowden Rory¹⁴⁶,Aneas Ivy³,Broxholme John¹,Humburg Peter¹,Iqbal Zamin¹,Lunter Gerton¹,Maller Julian¹⁴,Hernandez Ryan D.⁷,Melton Cord³,Venkat Aarti³⁵,Nobrega Marcelo A.³,Bontrop Ronald⁸,Myers Simon¹⁴,Donnelly Peter¹⁴,Przeworski Molly³⁵⁹,McVean Gil¹⁴

Affiliation:

1. Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

2. Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.

3. Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

4. Department of Statistics, 1 South Parks Road, University of Oxford, Oxford OX1 3TG, UK.

5. Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.

6. Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

7. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143–0912, USA.

8. Department of Comparative Genetics and Refinement, Biomedical Primate Research Center, Lange Kleiweg 139 2288 GJ, Rijswijk, Netherlands.

9. Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.

Abstract

Going Ape Over Genetic Maps Recombination is an important process in generating diversity and producing selectively advantageous genetic combinations. Thus, changes in recombination hotspots may influence speciation. To investigate the variation in recombination processes in humans and their closest existing relatives, Auton et al. (p. 193 , published online 15 March) prepared a fine-scale genetic map of the Western chimpanzee and compared it with that of humans. While rates of recombination are comparable between humans and chimpanzees, the locations and genetic motifs associated with recombination differ between the species.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. An evolutionary view of human recombination

2. Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination

3. Fine-scale recombination patterns differ between chimpanzees and humans

4. Absence of the TAP2 Human Recombination Hotspot in Chimpanzees

5. Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees

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