Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees-Reference-Cited by-同舟云学术

Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees

Published:2005-04 Issue:5718 Volume:308 Page:107-111
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Winckler Wendy¹²³⁴⁵,Myers Simon R.¹²³⁴⁵,Richter Daniel J.¹²³⁴⁵,Onofrio Robert C.¹²³⁴⁵,McDonald Gavin J.¹²³⁴⁵,Bontrop Ronald E.¹²³⁴⁵,McVean Gilean A. T.¹²³⁴⁵,Gabriel Stacey B.¹²³⁴⁵,Reich David¹²³⁴⁵,Donnelly Peter¹²³⁴⁵,Altshuler David¹²³⁴⁵

Affiliation:

1. Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114–2622, USA.

2. Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114–2622, USA.

3. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

4. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

5. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02141–2023, USA.

Abstract

We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite ∼99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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