The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair-Reference-Cited by-同舟云学术

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

Published:2009-12-18 Issue:5960 Volume:326 Page:1698-1701
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Knipscheer Puck¹,Räschle Markus²,Smogorzewska Agata³⁴,Enoiu Milica⁵,Ho The Vinh⁶,Schärer Orlando D.⁵⁶,Elledge Stephen J.³,Walter Johannes C.¹

Affiliation:

1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

3. Department of Genetics, Harvard Medical School, and Division of Genetics, Brigham and Women’s Hospital, Boston, MA 02115, USA.

4. Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

5. Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland.

6. Departments of Pharmacological Sciences and Chemistry, Stony Brook University, Stony Brook, NY 11794, USA.

Abstract

Fanconi Cross-Links Fanconi anemia is a rare genetic disease characterized by bone marrow failure, developmental abnormalities, and dramatically increased cancer susceptibility. Cells derived from Fanconi anemia patients are sensitive to agents that cause DNA interstrand cross-links, indicating that under normal circumstances the Fanconi pathway controls the repair of these DNA lesions. Knipscheer et al. (p. 1698 , published online 12 November) found that two Fanconi anemia proteins, FANCI and FANCD2, promoted the DNA replication–coupled repair of interstrand cross-links in cell extracts. The FANCI-FANCD2 complex was required for the incisions that unhook the cross-link and for the insertion of a nucleotide across from the damaged template base during lesion bypass.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. The Fanconi anaemia/BRCA pathway

2. Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

3. Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

4. Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

5. Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair

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