Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg2159.pdf
Reference106 articles.
1. Garcia-Higuera, I. et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell 7, 249–262 (2001). This work presents the first evidence for a DNA-damage response pathway that includes FA proteins and BRCA1, and shows that FANCD2 monoubiquitylation is a key step in this pathway.
2. Howlett, N. G. et al. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 297, 606–609 (2002). This study showed that BRCA2 is identical to FANCD1, providing the first direct evidence for a connection between breast cancer and FA.
3. Wang, X., Andreassen, P. R. & D'Andrea, A. D. Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol. Cell. Biol. 24, 5850–5862 (2004).
4. Venkitaraman, A. R. Tracing the network connecting BRCA and Fanconi anaemia proteins. Nature Rev. Cancer 4, 266–276 (2004).
5. Levitus, M. et al. The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. Nature Genet. 37, 934–935 (2005). One of the three papers that identified the BRCA1-interacting helicase BRIP1 as FANCJ, thus providing new connections between FA and breast cancer, and between FA and DNA repair.
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