CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins-Reference-Cited by-同舟云学术

CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins

Published:2013-12-20 Issue:6165 Volume:342 Page:1518-1521
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yu Chao¹,Zhang Yin-Li¹,Pan Wei-Wei¹,Li Xiao-Meng¹,Wang Zhong-Wei²,Ge Zhao-Jia²,Zhou Jian-Jie¹,Cang Yong¹,Tong Chao¹,Sun Qing-Yuan²,Fan Heng-Yu¹

Affiliation:

1. Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou 310058, China.

2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

Ubiquitin Fertility Insurance The female mammal's reproductive lifespan is determined by a pool of ovarian primordial follicles that are generated early in life. Yu et al. (p. 1518 ) found that in mice, the ubiquitin E3 ligase complex CRL4 is essential for oocyte survival within primordial follicles and for development after fertilization. CRL4 binds to and activates an adaptor protein that mediates ubiquitination, but if any component is deleted, the genes required for oocyte maintenance and early embryo development are silenced and the female mice become infertile.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles

2. CRL4s: the CUL4-RING E3 ubiquitin ligases

3. Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery

4. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8

5. Germ Cell-Specific Transcriptional Regulator Sohlh2 Is Essential for Early Mouse Folliculogenesis and Oocyte-Specific Gene Expression1

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