ROCK1 is a multifunctional factor maintaining the primordial follicle reserve and follicular development in mice-Reference-Cited by-同舟云学术

ROCK1 is a multifunctional factor maintaining the primordial follicle reserve and follicular development in mice

Published:2024-01-01 Issue:1 Volume:326 Page:C27-C39
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Zhang Tuo¹²³⁴⁵^ORCID,Lin Huan³,Ren Tianhe³,He Meina³⁴^ORCID,Zheng Wenying⁶,Tong Yuntong³,Jin Bangming¹²³⁴⁵,Xie Kaiyun³,Deng Ankang³,Liu Shiyu³,Chen Yuqian³,Xu Guoqiang³,Chen Tengxiang¹²³⁴⁵^ORCID,Pan Wei¹,Xiao Ziwen²

Affiliation:

1. Prenatal Diagnosis Center in Guizhou Province, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China

2. Department of Obstetrics and Gynecology, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China

3. Transformation Engineering Research Center of Chronic Disease Diagnosis and Treatment, Department of Physiology, College of Basic Medicine, Guizhou Medical University, Guiyang, People’s Republic of China

4. Guizhou Institute of Precision Medicine, Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China

5. Guizhou Provincial Key Laboratory of Pathogenesis & Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, People’s Republic of China

6. Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China

Abstract

ROCK1, one of the Rho GTPases, plays an important role in primordial follicle reserve and follicular development. ROCK1 was primarily expressed in the cytoplasm of oocytes and granulosa cell in mice. Inhibition of ROCK1 significantly reduced the primordial follicle reserve and delayed growing follicle development. ROCK1 regulates primordial follicular reserve and follicle development through the HIPPO signaling pathway. These findings shed new lights on the physiology of sustaining female reproduction.

Funder

Guizhou Provincial Science and Technology Project

Science and Technology Fund Project of Guizhou Provincial Health Commission

Excellent Young Talents Plan of Guizhou Medical University

Doctoral Startup Foundation of Guizhou Medical University

Continuous Support Fund for Excellent Scientific Research Platform of Colleges and Universities in Guizhou Province

Guizhou Provincial Natural Science Foundation

Innovation and Entrepreneurship Training Program for College Students in Guizhou Province

China Postdoctoral Science Foundation

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society