Class II-Independent Generation of CD4 Memory T Cells from Effectors-Reference-Cited by-同舟云学术

Class II-Independent Generation of CD4 Memory T Cells from Effectors

Published:1999-11-12 Issue:5443 Volume:286 Page:1381-1383
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Swain Susan L.¹,Hu Hui¹,Huston Gail¹

Affiliation:

1. Biomedical Research Laboratories, Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA.

Abstract

The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naı̈ve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II–deficient hosts, indicating no requirement for further antigen or class II recognition.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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