Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice-Reference-Cited by-同舟云学术

Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice

Published:2011-11-25 Issue:6059 Volume:334 Page:1133-1137
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Czupryn Artur¹²³,Zhou Yu-Dong⁴,Chen Xi⁵,McNay David⁵,Anderson Matthew P.⁴,Flier Jeffrey S.⁵⁶,Macklis Jeffrey D.¹²⁶

Affiliation:

1. Department of Stem Cell and Regenerative Biology, and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

2. MGH-HMS Center for Nervous System Repair, Departments of Neurology and Neurosurgery, and Program in Neuroscience, Harvard Medical School; Nayef Al-Rodhan Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA.

3. Nencki Institute of Experimental Biology, Department of Molecular and Cellular Neurobiology, Warsaw, 02-093, Poland.

4. Departments of Neurology and Pathology, and Program in Neuroscience, Harvard Medical School; Center for Life Sciences, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

5. Beth Israel Deaconess Medical Center, Division of Endocrinology, Diabetes, and Metabolism, and Harvard Medical School, Boston, MA 02215, USA.

6. Harvard Medical School, Boston, MA 02215, USA.

Abstract

Neurons transplanted from healthy donor mice can repair brain circuitry and partially normalize metabolism in obese mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

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