Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production-Reference-Cited by-同舟云学术

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

Published:2022-01-14 Issue:6577 Volume:375 Page:214-221
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Orecchioni Marco¹^ORCID,Kobiyama Kouji¹²,Winkels Holger¹³^ORCID,Ghosheh Yanal¹^ORCID,McArdle Sara⁴^ORCID,Mikulski Zbigniew⁴^ORCID,Kiosses William B.⁴^ORCID,Fan Zhichao¹⁵^ORCID,Wen Lai¹^ORCID,Jung Yunmin¹^ORCID,Roy Payel¹^ORCID,Ali Amal J.¹^ORCID,Miyamoto Yukiko⁶^ORCID,Mangan Matthew⁷,Makings Jeffrey¹,Wang Zhihao¹^ORCID,Denn Angela⁴^ORCID,Vallejo Jenifer¹^ORCID,Owens Michaela¹,Durant Christopher P.¹^ORCID,Braumann Simon³,Mader Navid⁸^ORCID,Li Lin⁹^ORCID,Matsunami Hiroaki¹⁰^ORCID,Eckmann Lars⁶^ORCID,Latz Eicke⁷,Wang Zeneng⁹^ORCID,Hazen Stanley L.⁹¹¹^ORCID,Ley Klaus¹¹²^ORCID

Affiliation:

1. La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

2. Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

3. Department of Internal Medicine III, Division of Cardiology, Heart Center, University Hospital of Cologne, 50937 Cologne, Germany.

4. Histology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

5. Department of Immunology, School of Medicine, UConn Health, University of Connecticut, Farmington, CT 06030, USA.

6. Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

7. Institute of Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.

8. Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, 50937 Cologne, Germany.

9. Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

10. Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27708, USA.

11. Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

12. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Sniffing out atherosclerosis Olfactory receptors are best known for their presence in the nose and their role in detecting smells, but they are also present in other tissues and perform additional biological functions. For example, vascular macrophages involved in the pathogenesis of atherosclerosis express multiple subtypes of olfactory receptors. Orecchioni et al . focused on olfactory receptor 2, a receptor for the compound octanal, and identified its contribution to atherosclerosis pathogenesis and the formation of atherosclerotic plaques (see the Perspective by Rayner and Rasheed). The authors show that most of the octanal was not directly derived from the diet, but rather was generated as a by-product of lipid peroxidation, suggesting a potential pathway for intervention. —YN

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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