Olfr2+ macrophages: monocyte-derived, pro-inflammatory foamy-like cells in atherosclerosis
Author:
Affiliation:
1. Institute of Experimental Biomedicine, University Hospital Würzburg , Josef-Schneider-Str. 2, D16, 97080 Würzburg , Germany
2. Paris Cardiovascular Research Center, Université Paris Cité, INSERM U970 , Paris , France
Funder
Deutsche Forschungsgemeinschaft
Publisher
Oxford University Press (OUP)
Link
https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvae183/59107935/cvae183.pdf
Reference10 articles.
1. Olfactory receptors are not unique to the nose;Drew;Nature,2022
2. Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production;Orecchioni;Science,2022
3. Olfr2-positive macrophages originate from monocytes proliferate in situ and present a pro-inflammatory foamy-like phenotype;Suthahar;Cardiovasc Res,2024
4. Integrated single-cell analysis based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis;Zernecke;Cardiovasc Res,2022
5. Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression;Williams;Nat Immunol,2020
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