Self-renewal of a purified Tie2 + hematopoietic stem cell population relies on mitochondrial clearance-Reference-Cited by-同舟云学术

Self-renewal of a purified Tie2 + hematopoietic stem cell population relies on mitochondrial clearance

Published:2016-12-02 Issue:6316 Volume:354 Page:1156-1160
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ito Kyoko¹²³,Turcotte Raphaël⁴,Cui Jinhua¹⁵,Zimmerman Samuel E.¹⁶,Pinho Sandra¹⁵,Mizoguchi Toshihide¹⁵,Arai Fumio⁷,Runnels Judith M.⁴,Alt Clemens⁴,Teruya-Feldstein Julie⁸,Mar Jessica C.¹⁶⁹,Singh Rajat²¹⁰¹¹,Suda Toshio⁷¹²,Lin Charles P.⁴,Frenette Paul S.¹²³⁵,Ito Keisuke¹²³⁵¹¹

Affiliation:

1. Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

2. Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

3. Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

4. Center for Systems Biology, Advanced Microscopy Program, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

5. Departments of Cell Biology and Stem Cell Institute, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

6. Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

7. Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Japan.

8. Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.

9. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

10. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

11. Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

12. Cancer Science Institute of Singapore, National University of Singapore, Singapore.

Abstract

Purified hematopoietic stem cells reveal that mitophagy plays a key role in their expansion.

Funder

NYSTEM (New York State Stem Cell Science)

Harvard Stem Cell Institute

Ellison Medical Foundation

NIH

Leukemia Lymphoma Society

Japan Society for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Metabolic requirements for the maintenance of self-renewing stem cells

2. Stem cell metabolism in tissue development and aging

3. A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

4. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

5. FOXO3A directs a protective autophagy program in haematopoietic stem cells

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