A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

Abstract

Keeping stem cells in tip top condition Stem cells are important in the maintenance and growth of tissues. For the health of the organism as a whole, it is important that only healthy stem cells be used. Mohrin et al. elucidated a regulatory branch of the mitochondrial unfolded protein response that is coupled to cellular energy metabolism and proliferation in stem cells (see the Perspective by Ocampo and Belmonte). Mitochondrial protein folding stress triggered a metabolic checkpoint that regulates the cell cycle. Deregulation of this pathway interfered with stem cell quiescence and compromised regenerative function. Science , this issue p. 1374 ; see also p. 1319