mGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination-Reference-Cited by-同舟云学术

mGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination

Published:2000-06-09 Issue:5472 Volume:288 Page:1832-1835
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ichise Taeko¹,Kano Masanobu²³,Hashimoto Kouichi²³,Yanagihara Dai²⁴⁵,Nakao Kazuki¹,Shigemoto Ryuichi²⁶,Katsuki Motoya¹²,Aiba Atsu¹

Affiliation:

1. Laboratory of DNA Biology and Embryo Engineering, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

2. Core Research for Evolutional Science and Technology (CREST),

3. Department of Physiology, School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan.

4. Toyohashi University of Technology, Toyohashi 441-8580, Japan.

5. Brain Science Institute, RIKEN, Wako 351-0198, Japan.

6. Laboratory of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan.

Abstract

Targeted deletion of metabotropic glutamate receptor–subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (–/–)] mice with a Purkinje cell (PC)–specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (–/–) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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