Oligodendrocyte precursors migrate along vasculature in the developing nervous system-Reference-Cited by-同舟云学术

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

Published:2016-01-22 Issue:6271 Volume:351 Page:379-384
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tsai Hui-Hsin¹,Niu Jianqin¹,Munji Roeben²,Davalos Dimitrios³,Chang Junlei⁴,Zhang Haijing⁴⁵⁶⁷,Tien An-Chi¹,Kuo Calvin J.⁴,Chan Jonah R.⁸,Daneman Richard²,Fancy Stephen P. J.¹⁸⁹¹⁰

Affiliation:

1. Department of Pediatrics, University of California at San Francisco (UCSF), San Francisco, CA 94158, USA.

2. Departments of Pharmacology and Neuroscience, University of California at San Diego (UCSD), San Diego, CA 92093, USA.

3. Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

4. Division of Hematology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

5. Department of Urology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

6. Howard Hughes Medical Institute (HHMI), Chevy Chase, MD 20815, USA.

7. Duke University School of Medicine, Durham, NC 27710, USA.

8. Department of Neurology, UCSF, San Francisco, CA 94158, USA.

9. Division of Neonatology, UCSF, San Francisco, CA 94158, USA.

10. Newborn Brain Research Institute, UCSF, San Francisco, CA 94158, USA.

Abstract

Neuronal migrations follow vascular pathways In the developing brain, various types of cells migrate from their birthplaces to their workplaces. Oligodendrocyte precursors, which develop to form the insulating sheaths that make signal transmission along an axon faster, travel farther than many. Tsai et al. now show just how the oligodendrocyte precursor cells find their way (see the Perspective by Dejana and Beltsholtz). The progenitor cells follow along the endothelial cells of the vasculature. Disrupting endothelial cells interfered with oligodendrocyte migration, leaving some sections of the brain deficient in insulators. Science , this issue p. 379 ; see also p. 341

Funder

University of California

National Institute of Neurological Disorders and Stroke

HHMI

American Heart Association

NIH

National Multiple Sclerosis Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.