Gene essentiality and synthetic lethality in haploid human cells

Author:

Blomen Vincent A.1,Májek Peter2,Jae Lucas T.1,Bigenzahn Johannes W.2,Nieuwenhuis Joppe1,Staring Jacqueline1,Sacco Roberto2,van Diemen Ferdy R.1,Olk Nadine2,Stukalov Alexey2,Marceau Caleb3,Janssen Hans1,Carette Jan E.3,Bennett Keiryn L.2,Colinge Jacques24,Superti-Furga Giulio25,Brummelkamp Thijn R.126

Affiliation:

1. Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.

2. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

3. Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA.

4. University of Montpellier, Institut de Recherche en Cancérologie de Montpellier Inserm U1194, Institut régional du Cancer Montpellier, 34000 Montpellier, France.

5. Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

6. Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066CX, Amsterdam, Netherlands.

Funder

Cancer Genomics Center

European Research Council (ERC)

Austrian Academy of Sciences

Austrian Science Fund

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)

ARC Foundation

VIDI

Advanced ERC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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