Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Author:

Atarashi Koji1,Tanoue Takeshi1,Shima Tatsuichiro2,Imaoka Akemi2,Kuwahara Tomomi3,Momose Yoshika4,Cheng Genhong5,Yamasaki Sho6,Saito Takashi6,Ohba Yusuke7,Taniguchi Tadatsugu1,Takeda Kiyoshi8,Hori Shohei9,Ivanov Ivaylo I.10,Umesaki Yoshinori2,Itoh Kikuji4,Honda Kenya111

Affiliation:

1. Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.

2. Yakult Central Institute for Microbiological Research, Tokyo 186-8650, Japan.

3. Department of Molecular Bacteriology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan.

4. Department of Veterinary Public Health, University of Tokyo, Tokyo 113-8657, Japan.

5. Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

6. Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan.

7. Laboratory of Pathophysiology and Signal Transduction, Hokkaido University, Graduate School of Medicine, Sapporo 060-8638, Japan.

8. Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.

9. Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan.

10. Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

11. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama 332-0012, Japan.

Abstract

Bacteria of the genus Clostridium promote the induction of suppressor T cells in the colons of mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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