Affiliation:
1. Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143–0414, USA.
Abstract
The pathogenic yeast
Candida albicans
regulates its cellular morphology in response to environmental conditions. Ellipsoidal, single cells (blastospores) predominate in rich media, whereas filaments composed of elongated cells that are attached end-to-end form in response to starvation, serum, and other conditions. The
TUP1
gene, which encodes a general transcriptional repressor in
Saccharomyces cerevisiae
, was isolated from
C. albicans
and disrupted. The resulting
tup1
mutant strain of
C. albicans
grew exclusively as filaments under all conditions tested.
TUP1
was epistatic to the transcriptional activator
CPH1
, previously found to promote filamentous growth. The results suggest a model where
TUP1
represses genes responsible for initiating filamentous growth and this repression is lifted under inducing environmental conditions.
Publisher
American Association for the Advancement of Science (AAAS)
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