Alpha1-antitrypsin impacts innate host–pathogen interactions with Candida albicans by stimulating fungal filamentation

Author:

Jaeger Martin12ORCID,Dietschmann Axel3ORCID,Austermeier Sophie4ORCID,Dinçer Sude3ORCID,Porschitz Pauline3ORCID,Vornholz Larsen5ORCID,Maas Ralph J.A.16,Sprenkeler Evelien G.G.2,Ruland Jürgen578ORCID,Wirtz Stefan9ORCID,Azam Tania1,Joosten Leo A.B.2,Hube Bernhard410ORCID,Netea Mihai G.2,Dinarello Charles A.12,Gresnigt Mark S.13ORCID

Affiliation:

1. Department of Medicine, University of Colorado Denver, Aurora, USA

2. Department of Internal Medicine, Radboud University Medical Center and Radboud Center for Infectious diseases (RCI), Nijmegen, the Netherlands

3. Junior Research Group Adaptive Pathogenicity Strategies, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany

4. Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany

5. Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany

6. Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands

7. German Cancer Consortium (DKTK), partner site Munich, Germany

8. German Center for Infection Research (DZIF), partner site Munich, Germany

9. Medizinische Klinik 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

10. Institute of Microbiology, Friedrich-Schiller-University, Jena, Germany

Funder

Deutsche Forschungsgemeinschaft

European Society of Clinical Microbiology and Infectious Diseases

Horizon 2020

Publisher

Informa UK Limited

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