Preexisting and de novo humoral immunity to SARS-CoV-2 in humans-Reference-Cited by-同舟云学术

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Published:2020-12-11 Issue:6522 Volume:370 Page:1339-1343
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ng Kevin W.¹^ORCID,Faulkner Nikhil¹^ORCID,Cornish Georgina H.¹^ORCID,Rosa Annachiara²^ORCID,Harvey Ruth³,Hussain Saira³^ORCID,Ulferts Rachel⁴,Earl Christopher⁵^ORCID,Wrobel Antoni G.⁶^ORCID,Benton Donald J.⁶^ORCID,Roustan Chloe⁷^ORCID,Bolland William¹,Thompson Rachael¹,Agua-Doce Ana⁸^ORCID,Hobson Philip⁸^ORCID,Heaney Judith⁹,Rickman Hannah⁹^ORCID,Paraskevopoulou Stavroula⁹,Houlihan Catherine F.⁹¹⁰^ORCID,Thomson Kirsty⁹^ORCID,Sanchez Emilie⁹,Shin Gee Yen⁹^ORCID,Spyer Moira J.⁹¹¹^ORCID,Joshi Dhira¹²^ORCID,O’Reilly Nicola¹²^ORCID,Walker Philip A.⁷^ORCID,Kjaer Svend⁷^ORCID,Riddell Andrew⁸,Moore Catherine¹³^ORCID,Jebson Bethany R.¹⁴¹⁵^ORCID,Wilkinson Meredyth¹⁴¹⁵^ORCID,Marshall Lucy R.¹⁴¹⁵,Rosser Elizabeth C.¹⁴¹⁶^ORCID,Radziszewska Anna¹⁴¹⁶^ORCID,Peckham Hannah¹⁴¹⁶^ORCID,Ciurtin Coziana¹⁴¹⁶^ORCID,Wedderburn Lucy R.¹⁴¹⁵,Beale Rupert⁴^ORCID,Swanton Charles¹⁷^ORCID,Gandhi Sonia¹⁸,Stockinger Brigitta¹⁹^ORCID,McCauley John³^ORCID,Gamblin Steve J.⁶^ORCID,McCoy Laura E.¹⁰^ORCID,Cherepanov Peter²^ORCID,Nastouli Eleni⁹¹¹^ORCID,Kassiotis George¹²⁰^ORCID

Affiliation:

1. Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.

2. Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

3. Worldwide Influenza Centre, The Francis Crick Institute, London NW1 1AT, UK.

4. Cell Biology of Infection Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

5. Signalling and Structural Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

6. Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

7. Structural Biology STP, The Francis Crick Institute, London NW1 1AT, UK.

8. Flow Cytometry STP, The Francis Crick Institute, London NW1 1AT, UK.

9. University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.

10. Division of Infection and Immunity, University College London (UCL), London WC1E 6BT, UK.

11. Department of Population, Policy and Practice, Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.

12. Peptide Chemistry, The Francis Crick Institute, London NW1 1AT, UK.

13. Public Health Wales, University Hospital of Wales, Cardiff CF14 4XW, UK.

14. Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.

15. UCL Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.

16. Centre for Rheumatology Research, Division of Medicine, UCL, London, WC1E 6BT, UK.

17. Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

18. Neurodegeneration Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

19. AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

20. Department of Medicine, Faculty of Medicine, Imperial College London, London W2 1PG, UK.

Abstract

Antibodies predating infection Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ng et al. report that in a cohort of 350 SARS-CoV-2–uninfected individuals, a small proportion had circulating immunoglobulin G (IgG) antibodies that could cross-react with the S2 subunit of the SARS-CoV-2 spike protein (see the Perspective by Guthmiller and Wilson). By contrast, COVID-19 patients generated IgA, IgG, and IgM antibodies that recognized both the S1 and S2 subunits. The anti-S2 antibodies from SARS-CoV-2–uninfected patients showed specific neutralizing activity against both SARS-CoV-2 and SARS-CoV-2 S pseudotypes. A much higher percentage of SARS-CoV-2–uninfected children and adolescents were positive for these antibodies compared with adults. This pattern may be due to the fact that children and adolescents generally have higher hCoV infection rates and a more diverse antibody repertoire, which may explain the age distribution of COVID-19 susceptibility. Science , this issue p. 1339 ; see also p. 1272

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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