Evolution of MRSA During Hospital Transmission and Intercontinental Spread-Reference-Cited by-同舟云学术

Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Published:2010-01-22 Issue:5964 Volume:327 Page:469-474
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Harris Simon R.¹,Feil Edward J.²,Holden Matthew T. G.¹,Quail Michael A.¹,Nickerson Emma K.³⁴,Chantratita Narisara³,Gardete Susana⁵⁶,Tavares Ana⁵,Day Nick³⁷,Lindsay Jodi A.⁸,Edgeworth Jonathan D.⁹¹⁰,de Lencastre Hermínia⁵⁶,Parkhill Julian¹,Peacock Sharon J.³⁴,Bentley Stephen D.¹

Affiliation:

1. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.

2. Department of Biology and Biochemistry, University of Bath, South Building, Claverton Down, Bath BA2 7AY, UK.

3. Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

4. Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.

5. Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal.

6. Laboratory of Microbiology, The Rockefeller University, New York, NY 10065, USA.

7. Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK.

8. Centre for Infection, Department of Cellular and Molecular Medicine, St. George’s, University of London, Cranmer Terrace, London SW17 0RE, UK.

9. Department of Infectious Diseases, King’s College London, Guy’s, King’s, and St. Thomas’ Medical School, Guy’s Hospital, London SE1 9RT, UK.

10. Directorate of Infection, Guy’s and St. Thomas’ National Health Service Foundation Trust, London SE1 7EH, UK.

Abstract

MRSA, Close and Personal Methods for differentiating pathogen isolates are essential for understanding their evolution and spread, as well as for the formulation of effective clinical strategies. Current typing methods for bacterial pathogens focus on a limited set of characteristics providing data with limited resolving power. Harris et al. (p. 469 ) used a high-throughput genome sequencing approach to show that isolates of methicillin-resistant Staphylococcus aureus (MRSA) are precisely differentiated into a global geographic structure. The findings suggest that intercontinental transmission has occurred for nearly four decades. The method could also detect individual person-to-person transmission events of MRSA within a hospital environment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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