Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan-Reference-Cited by-同舟云学术

Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan

Published:2014-05-02 Issue:6183 Volume:344 Page:523-527
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gokhman David¹,Lavi Eitan¹,Prüfer Kay²,Fraga Mario F.³,Riancho José A.⁴,Kelso Janet²,Pääbo Svante²,Meshorer Eran¹⁵,Carmel Liran¹

Affiliation:

1. Department of Genetics, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel.

2. Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.

3. Cancer Epigenetics Laboratory, University Institute of Oncology of Asturias–Cajastur Social Program (IUOPA), University of Oviedo, Oviedo and Centro Nacional de Biotecnologia–Consejo Superior de Investigaciones Científicas, Madrid, Spain.

4. Department of Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, Instituto de Investigación Marqués de Valdecilla, Santander, Spain.

5. Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Abstract

Methylating the Family Tree DNA sequences show a high level of similarities between humans and ancient hominids but the degree to which there are differences between methylated regions in their genomes that may explain phenotypic differences is unclear. Gokhman et al. (p. 523 , published online 17 April) demonstrate that naturally degraded methylated cytosines in ancient DNA are converted to thymines and can be used to reconstruct ancient methylomes. The results suggest differences in methylation in bone tissues between modern humans and ancient hominids in a set of genes important for limb development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

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2. The complete genome sequence of a Neanderthal from the Altai Mountains

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5. Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA

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