A High-Coverage Genome Sequence from an Archaic Denisovan Individual-Reference-Cited by-同舟云学术

A High-Coverage Genome Sequence from an Archaic Denisovan Individual

Published:2012-10-12 Issue:6104 Volume:338 Page:222-226
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Meyer Matthias¹,Kircher Martin¹,Gansauge Marie-Theres¹,Li Heng²,Racimo Fernando¹,Mallick Swapan²³,Schraiber Joshua G.⁴,Jay Flora⁴,Prüfer Kay¹,de Filippo Cesare¹,Sudmant Peter H.⁵,Alkan Can⁶⁵,Fu Qiaomei¹⁷,Do Ron²,Rohland Nadin²³,Tandon Arti²³,Siebauer Michael¹,Green Richard E.⁸,Bryc Katarzyna³,Briggs Adrian W.³,Stenzel Udo¹,Dabney Jesse¹,Shendure Jay⁵,Kitzman Jacob⁵,Hammer Michael F.⁹,Shunkov Michael V.¹⁰,Derevianko Anatoli P.¹⁰,Patterson Nick²,Andrés Aida M.¹,Eichler Evan E.⁵¹¹,Slatkin Montgomery⁴,Reich David²³,Kelso Janet¹,Pääbo Svante¹

Affiliation:

1. Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.

2. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.

3. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

4. Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

5. Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.

6. Department of Computer Engineering, Bilkent University, 06800 Ankara, Turkey.

7. CAS-MPS Joint Laboratory for Human Evolution, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, 100044 Beijing, China.

8. Jack Baskin School of Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.

9. Arizona Research Laboratories, Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USA.

10. Palaeolithic Department, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 630090 Novosibirsk, Russia.

11. Howard Hughes Medical Institute, Seattle, WA 98195, USA.

Abstract

Ancient Genomics The Denisovans were archaic humans closely related to Neandertals, whose populations overlapped with the ancestors of modern-day humans. Using a single-stranded library preparation method, Meyer et al. (p. 222 , published online 30 August) provide a detailed analysis of a high-quality Denisovan genome. The genomic sequence provides evidence for very low rates of heterozygosity in the Denisova, probably not because of recent inbreeding, but instead because of a small population size. The genome sequence also illuminates the relationships between humans and archaics, including Neandertals, and establishes a catalog of genetic changes within the human lineage.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference195 articles.

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5. Who Were the Denisovans?

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