Rapid increase in Omicron infections in England during December 2021: REACT-1 study-Reference-Cited by-同舟云学术

Rapid increase in Omicron infections in England during December 2021: REACT-1 study

Published:2022-03-25 Issue:6587 Volume:375 Page:1406-1411
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Elliott Paul¹²³⁴⁵^ORCID,Bodinier Barbara¹²^ORCID,Eales Oliver¹⁶^ORCID,Wang Haowei¹⁶^ORCID,Haw David¹⁶^ORCID,Elliott Joshua³⁷^ORCID,Whitaker Matthew¹²^ORCID,Jonnerby Jakob¹⁸,Tang David¹²^ORCID,Walters Caroline E.¹⁶^ORCID,Atchison Christina¹³^ORCID,Diggle Peter J.⁵⁹^ORCID,Page Andrew J.¹⁰^ORCID,Trotter Alexander J.¹⁰^ORCID,Ashby Deborah¹^ORCID,Barclay Wendy⁷^ORCID,Taylor Graham⁷^ORCID,Ward Helen¹³⁴⁶^ORCID,Darzi Ara³⁴¹¹^ORCID,Cooke Graham S.³⁴⁷^ORCID,Chadeau-Hyam Marc¹²^ORCID,Donnelly Christl A.¹⁶¹²^ORCID

Affiliation:

1. School of Public Health, Imperial College London, London, UK.

2. MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

3. Imperial College Healthcare NHS Trust, London, UK.

4. National Institute for Health Research Imperial Biomedical Research Centre, London, UK.

5. Health Data Research (HDR) UK, Imperial College London, London, UK.

6. MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.

7. Department of Infectious Disease, Imperial College London, London, UK.

8. National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK.

9. CHICAS, Lancaster Medical School, Lancaster University, Lancaster, UK.

10. Quadram Institute, Norwich, UK.

11. Institute of Global Health Innovation, Imperial College London, London, UK.

12. Department of Statistics, University of Oxford, Oxford, UK.

Abstract

The unprecedented rise in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed the prevalence of SARS-CoV-2 and its dynamics in England from the end of November to mid-December 2021 among almost 100,000 participants in the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, with an increasing proportion of infections due to Omicron. We observed large decreases in swab positivity among mostly vaccinated older children (12 to 17 years) relative to unvaccinated younger children (5 to 11 years), and in adults who received a third (booster) vaccine dose versus two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. F. Schmidt et al . Plasma neutralization properties of the SARS-CoV-2 Omicron variant. bioRxiv 21267646 (2021). 10.1101/2021.12.12.21267646

2. Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months

3. REal-time Assessment of Community Transmission (REACT) of SARS-CoV-2 virus: Study protocol

4. Resurgence of SARS-CoV-2: Detection by community viral surveillance

5. Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant

Cited by 92 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants;npj Vaccines;2024-01-02

2. Comparison of metagenomic and targeted methods for sequencing human pathogenic viruses from wastewater;mBio;2023-12-19

3. Comparing the immune response and protective effect of COVID-19 vaccine under different vaccination strategies;Human Vaccines & Immunotherapeutics;2023-12-15

4. Epidemiological features of SARS-CoV-2 Omicron infection under new control strategy: a cross-sectional study of the outbreak since December 2022 in Sichuan, China;BMC Public Health;2023-12-08

5. Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution;Nature Communications;2023-11-21