Dengue diversity across spatial and temporal scales: Local structure and the effect of host population size

Author:

Salje Henrik1234ORCID,Lessler Justin1ORCID,Maljkovic Berry Irina5ORCID,Melendrez Melanie C.5ORCID,Endy Timothy6ORCID,Kalayanarooj Siripen7,A-Nuegoonpipat Atchareeya8ORCID,Chanama Sumalee8ORCID,Sangkijporn Somchai8,Klungthong Chonticha9,Thaisomboonsuk Butsaya9,Nisalak Ananda9,Gibbons Robert V.9ORCID,Iamsirithaworn Sopon10ORCID,Macareo Louis R.9,Yoon In-Kyu911ORCID,Sangarsang Areerat8,Jarman Richard G.5ORCID,Cummings Derek A. T.11213ORCID

Affiliation:

1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

2. Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Paris, France.

3. CNRS, URA3012, Paris 75015, France.

4. Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France.

5. Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.

6. Department of Medicine, Upstate Medical University of New York, Syracuse, New York, NY, 13210, USA.

7. Queen Sirikit National Institute of Child Health, Bangkok, Thailand.

8. National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.

9. Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

10. Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.

11. International Vaccine Institute, Seoul, South Korea.

12. Department of Biology, University of Florida, Gainesville, FL 32610, USA.

13. Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA.

Abstract

Regions of high human population density drive highly localized transmission chains of dengue virus, which then can disperse regionally.

Funder

National Science Foundation

National Institutes of Health

Global Emerging Infections Surveillance and Response System

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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