Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation-Reference-Cited by-同舟云学术

Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation

Published:2014-01-17 Issue:6168 Volume:343 Page:313-317
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ravindran Rajesh¹,Khan Nooruddin¹²,Nakaya Helder I.¹³,Li Shuzhao¹,Loebbermann Jens¹,Maddur Mohan S.¹,Park Youngja⁴,Jones Dean P.⁵,Chappert Pascal⁶⁷,Davoust Jean⁶⁷,Weiss David S.⁸,Virgin Herbert W.⁹,Ron David¹⁰,Pulendran Bali¹³

Affiliation:

1. Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.

2. Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.

3. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA.

4. College of Pharmacy, Korea University, 339-700 Korea.

5. Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA 30322, USA.

6. Institut National de la Santé et de la Recherche Médicale U1013, Paris, France.

7. Université Paris Descartes, Sorbonne Paris Cité, Paris 75743 Paris Cedex 15, France.

8. Department of Medicine, Division of Infectious Diseases, Emory University, Atlanta, GA 30329, USA .

9. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

10. University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.

Abstract

The Secret Life of a Vaccine Antigen-specific CD8 ÷ T cells play a central role in the adaptive immune response to viral infections and to cancer.

Ravindran et al.

(p. 313 , published online 5 December) studied the successful yellow fever virus vaccine YF-17D to gain insight into its mechanism of action. The vaccine activated the nutrient deprivation sensor, GCN2 kinase, in dendritic cells. In transgenic mouse models, GCN2 activation promoted autophagy and antigen cross-presentation, enhancing the virus-specific CD8 ÷ T cell response. The findings suggest an important role for nutrient availability and autophagy in vaccine efficacy, which could aid more successful vaccine development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

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