Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex-Reference-Cited by-同舟云学术

Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex

Published:2005-03-18 Issue:5716 Volume:307 Page:1776-1778
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hao Shuzhen¹²³⁴⁵,Sharp James W.¹²³⁴⁵,Ross-Inta Catherine M.¹²³⁴⁵,McDaniel Brent J.¹²³⁴⁵,Anthony Tracy G.¹²³⁴⁵,Wek Ronald C.¹²³⁴⁵,Cavener Douglas R.¹²³⁴⁵,McGrath Barbara C.¹²³⁴⁵,Rudell John B.¹²³⁴⁵,Koehnle Thomas J.¹²³⁴⁵,Gietzen Dorothy W.¹²³⁴⁵

Affiliation:

1. School of Veterinary Medicine, Department of Anatomy, Physiology and Cell Biology, University of California, Davis, CA 95616, USA.

2. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, IN 47712, USA.

3. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

4. Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA.

5. Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Abstract

Recognizing a deficiency of indispensable amino acids (IAAs) for protein synthesis is vital for dietary selection in metazoans, including humans. Cells in the brain's anterior piriform cortex (APC) are sensitive to IAA deficiency, signaling diet rejection and foraging for complementary IAA sources, but the mechanism is unknown. Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (eIF2) via the GC nonderepressing 2 (GCN2) kinase. Thus, a basic mechanism of nutritional stress management functions in mammalian brain to guide food selection for survival.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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