Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding-Reference-Cited by-同舟云学术

Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding

Published:2010-05-21 Issue:5981 Volume:328 Page:1036-1040
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Schmidt Dominic¹²,Wilson Michael D.¹²,Ballester Benoit³,Schwalie Petra C.³,Brown Gordon D.¹,Marshall Aileen¹⁴,Kutter Claudia¹,Watt Stephen¹,Martinez-Jimenez Celia P.⁵,Mackay Sarah⁶,Talianidis Iannis⁵,Flicek Paul³⁷,Odom Duncan T.¹²

Affiliation:

1. Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

2. University of Cambridge, Department of Oncology, Hutchison/Medical Research Council Research Centre, Hills Road, Cambridge CB2 0XZ, UK.

3. European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

4. Cambridge Hepatobiliary Service, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.

5. Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Greece.

6. Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, G128QQ, UK.

7. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

Abstract

Subtle Variation Despite vast phenotypic differences, vertebrates have many readily recognizable specific cell types, like liver hepatocytes. The gene expression that defines specific cells depends on evolutionarily conserved orthologous transcription factors. Schmidt et al. (p. 1036 , published online 8 April) studied the conservation and divergence in the genome-wide binding of two such transcription factors, CEBPA and HNF4A, in livers from human, dog, mouse, short-tailed opossum, and chicken. Although the sequence bound by orthologous transcription factors was similar, the vast majority of binding events were unique to each species.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

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