Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants-Reference-Cited by-同舟云学术

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

Published:2022-01-14 Issue:6577 Volume:375 Page:183-192
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Reynolds Catherine J.¹^ORCID,Gibbons Joseph M.²^ORCID,Pade Corinna²^ORCID,Lin Kai-Min¹^ORCID,Sandoval Diana Muñoz¹^ORCID,Pieper Franziska¹^ORCID,Butler David K.¹^ORCID,Liu Siyi¹^ORCID,Otter Ashley D.³^ORCID,Joy George⁴^ORCID,Menacho Katia⁴^ORCID,Fontana Marianna⁵^ORCID,Smit Angelique⁵^ORCID,Kele Beatrix⁴^ORCID,Cutino-Moguel Teresa⁴^ORCID,Maini Mala K.⁶^ORCID,Noursadeghi Mahdad⁶^ORCID,Brooks Tim³^ORCID,Semper Amanda³^ORCID,Manisty Charlotte⁴⁷^ORCID,Treibel Thomas A.⁴⁷^ORCID,Moon James C.⁴⁷^ORCID,McKnight Áine²^ORCID,Altmann Daniel M.⁸^ORCID,Boyton Rosemary J.¹⁹^ORCID, ,

Affiliation:

1. Department of Infectious Disease, Imperial College London, London, UK.

2. Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

3. UK Health Security Agency, Porton Down, UK.

4. St. Bartholomew’s Hospital, Barts Health NHS Trust, London, UK.

5. Royal Free London NHS Foundation Trust, London, UK.

6. Division of Infection and Immunity, University College London, London, UK.

7. Institute of Cardiovascular Science, University College London, London, UK.

8. Department of Immunology and Inflammation, Imperial College London, London, UK.

9. Lung Division, Royal Brompton and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK.

Abstract

Immune imprinting For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immune responses to heterologous variants are influenced by a person’s infection history. Healthcare workers (HCWs) may be exposed to several doses and types of antigens, either by natural infection or by vaccination. Reynolds et al . studied a cohort of UK HCWs followed since March 2020. The immunological profiles of these people depended on how often the subject had encountered antigen and which variant was involved. Vaccine responses after infection were found to be less effective if the infection involved heterologous spike from a variant virus. Unfortunately, the N501Y spike mutation, found in many variants, seems to induce the regulatory T cell transcription factor FOXP3, indicating that the virus could subvert effective T cell function. Changes to antibody binding between variants also means that serology data using the Wuhan Hu-1 S1 receptor-binding domain sequence may not be a reliable measure of protection. —CA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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