Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes-Reference-Cited by-同舟云学术

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

Published:2016-04-15 Issue:6283 Volume:352 Page:349-353
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Goodman Christopher D.¹,Siregar Josephine E.¹²³,Mollard Vanessa¹,Vega-Rodríguez Joel⁴,Syafruddin Din²⁵,Matsuoka Hiroyuki⁶,Matsuzaki Motomichi³,Toyama Tomoko¹,Sturm Angelika¹,Cozijnsen Anton¹,Jacobs-Lorena Marcelo⁴,Kita Kiyoshi³⁷,Marzuki Sangkot²,McFadden Geoffrey I.¹

Affiliation:

1. School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.

2. Eijkman Institute for Molecular Biology, JI Diponegoro no. 69, Jakarta, 10430, Indonesia.

3. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

4. Johns Hopkins University Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA.

5. Department of Parasitology, Faculty of Medicine, Hasanuddin University, Jalan Perintis Kemerdekaan Km10, Makassar 90245, Indonesia.

6. Division of Medical Zoology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

7. School of Tropical Medicine and Global Health, Nagasaki University, Sakamoto, Nagasaki 852-8523, Japan.

Abstract

Transmission blocked by drug resistance Resistance to the antimalarial drug atovaquone might prove to be this parasite's weak spot. Resistance develops rapidly via mutations in the drug's target: the parasite's mitochondrial cytochrome b complex. Goodman et al. have discovered that although resistant Plasmodium berghei parasites persist in mice, in blood-sucking malarial mosquitoes, the mutations disable female parasites too much for them to reproduce. The human-specific Plasmodium falciparum can only be investigated experimentally in mosquitoes, but a similar effect was seen. Thus, atovaquone-resistant parasites cannot be transmitted to another mammal or person. Science , this issue p. 349

Funder

National Health and Medical Research Council

Australian Research Council

Indonesian Ministry of Research, Technology, and Higher Education

U.S. National Institutes of Health

Japanese Society for Promotion of Science (JSPS) KAKENHI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. Antimalarial pharmacology and therapeutics of atovaquone