Systematic analysis of complex genetic interactions-Reference-Cited by-同舟云学术

Systematic analysis of complex genetic interactions

Published:2018-04-20 Issue:6386 Volume:360 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kuzmin Elena¹²^ORCID,VanderSluis Benjamin³^ORCID,Wang Wen³^ORCID,Tan Guihong¹^ORCID,Deshpande Raamesh³,Chen Yiqun¹,Usaj Matej¹^ORCID,Balint Attila¹⁴^ORCID,Mattiazzi Usaj Mojca¹,van Leeuwen Jolanda¹,Koch Elizabeth N.³^ORCID,Pons Carles³^ORCID,Dagilis Andrius J.⁵^ORCID,Pryszlak Michael¹^ORCID,Wang Jason Zi Yang¹²,Hanchard Julia¹²^ORCID,Riggi Margot⁶⁷⁸⁹,Xu Kaicong³^ORCID,Heydari Hamed¹²^ORCID,San Luis Bryan-Joseph¹,Shuteriqi Ermira¹,Zhu Hongwei¹,Van Dyk Nydia¹,Sharifpoor Sara¹^ORCID,Costanzo Michael¹^ORCID,Loewith Robbie⁶⁸⁹^ORCID,Caudy Amy¹²^ORCID,Bolnick Daniel⁵^ORCID,Brown Grant W.¹⁴^ORCID,Andrews Brenda J.¹²^ORCID,Boone Charles¹²¹⁰^ORCID,Myers Chad L.³^ORCID

Affiliation:

1. The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

2. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

3. Department of Computer Science and Engineering, University of Minnesota–Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.

4. Department of Biochemistry, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

5. Department of Integrative Biology, 1 University Station C0990, University of Texas at Austin, Austin, TX 78712, USA.

6. Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland.

7. Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland.

8. iGE3 (Institute of Genetics and Genomics of Geneva), 1211 Geneva, Switzerland.

9. Swiss National Centre for Competence in Research Programme Chemical Biology, 1211 Geneva, Switzerland.

10. RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.

Abstract

Trigenic interactions in yeast link bioprocesses To dissect the genotype-phenotype landscape of a cell, it is necessary to understand interactions between genes. Building on the digenic protein-protein interaction network, Kuzmin et al. created a trigenic landscape of yeast by using a synthetic genetic array (see the Perspective by Walhout). Triple-mutant analyses indicated that the majority of genes with trigenic associations functioned within the same biological processes. These converged on networks identified in the digenic interaction landscape. Although the overall effects were weaker for trigenic than for digenic interactions, trigenic interactions were more likely to bridge biological processes in the cell. Science , this issue p. eaao1729 ; see also p. 269

Funder

National Science Foundation

National Institutes of Health

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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1. Principles for the Buffering of Genetic Variation