Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals-Reference-Cited by-同舟云学术

Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals

Published:2016-04-08 Issue:6282 Volume:352 Page:235-239
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Vernot Benjamin¹,Tucci Serena¹²,Kelso Janet³,Schraiber Joshua G.¹,Wolf Aaron B.¹,Gittelman Rachel M.¹,Dannemann Michael³,Grote Steffi³,McCoy Rajiv C.¹,Norton Heather⁴,Scheinfeldt Laura B.⁵,Merriwether David A.⁶,Koki George⁷,Friedlaender Jonathan S.⁸,Wakefield Jon⁹,Pääbo Svante³,Akey Joshua M.¹

Affiliation:

1. Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

2. Department of Life Sciences and Biotechnology, University of Ferrara, Italy.

3. Department of Evolutionary Genetics, Max-Planck-Institute for Evolutionary Anthropology, Leipzig, Germany.

4. Department of Anthropology, University of Cincinnati, Cincinnati, OH, USA.

5. Department of Biology and Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, USA.

6. Department of Anthropology, Binghamton University, Binghamton, NY, USA.

7. Institute for Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea.

8. Department of Anthropology, Temple University, Philadelphia PA, USA.

9. Department of Statistics, University of Washington, Seattle, Washington, USA.

Abstract

Denisovan DNA retained in Melanesians Modern humans carry remnants of DNA from interbreeding events with archaic lineages, such as Neandertals. However, people from Oceania also retain genes from a second ancient lineage, the Denisovans. Vernot et al. surveyed archaic genomic sequences in a worldwide sample of modern humans, including 35 individuals from the Melanesian Islands. All non-African genomes surveyed contained Neandertal DNA, but a significant Denisovan component was found only in the Melanesians. Reconstruction of this genetic history suggests that Neandertals bred with modern humans multiple times, but Denosivans only once, in ancestors of modern-day Melanesians. Science , this issue p. 235

Funder

NIH

Deutsche Forschungsgemeinschaft

Max Planck Society

NSF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference72 articles.

1. Small Amounts of Archaic Admixture Provide Big Insights into Human History

2. A Draft Sequence of the Neandertal Genome