Affiliation:
1. Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Abstract
Bright future ahead for crystallography
Macromolecular x-ray crystallography typically provides static snapshots of systems at equilibrium. Advances in time-resolved crystallography have made it possible to capture dynamics in biomolecules: large and small, fast and slow. Brändén and Neutze review techniques and concepts that have emerged from recent work at x-ray free electron laser sources and are now being applied in other settings and to a growing number of biological systems. Despite challenges in analyzing and relating these data to a biological context, experiments in this field have opened new frontiers in temporal and spatial resolution and yielded many new insights into nonequilibrium chemistry and conformational changes in biology. —MAF
Funder
Horizon 2020 Framework Programme
Swedish Foundation for Strategic Research
Vetenskapsrådet
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
80 articles.
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