Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion-Reference-Cited by-同舟云学术

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

Published:2017-10-27 Issue:6362 Volume:358 Page:518-522
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nasamu Armiyaw S.¹²^ORCID,Glushakova Svetlana³^ORCID,Russo Ilaria⁴^ORCID,Vaupel Barbara¹²,Oksman Anna¹²,Kim Arthur S.¹⁵^ORCID,Fremont Daved H.⁵,Tolia Niraj²,Beck Josh R.¹²,Meyers Marvin J.⁶^ORCID,Niles Jacquin C.⁷^ORCID,Zimmerberg Joshua³^ORCID,Goldberg Daniel E.¹²^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.

2. Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

3. Section on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

4. Faculty of Biology, Medicine and Health, Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK.

5. Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

6. Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.

7. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Plasmodium parasite entrance and exit Sweats and fever are the hallmarks of malaria. Red blood cells are the replication factories for malaria parasites. Fever occurs when the parasites' merozoite stages burst en masse from red blood cells into the circulation. Nasamu et al. and Pino et al. discovered that two parasite proteases, plasmepsin IX and X, are essential for mass cell exit (see the Perspective by Boddey). Plasmepsin X is also used by the merozoites to enter a fresh red blood cell to continue the replicative cycle. These two plasmepsins act by regulating the maturation of enzymes required to disrupt host cell membranes. Because these functions are essential for the parasite, the authors used protease inhibitors to show that plasmepsins provide potential drug targets. Science , this issue p. 518 , p. 522 ; see also p. 445

Funder

NIH Office of the Director

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Recent Advances in Plasmepsin Medicinal Chemistry and Implications for Future Antimalarial Drug Discovery Efforts

2. Inhibitors of the Plasmodium Falciparum Parasite Aspartic Protease Plasmepsin II As Potential Antimalarial Agents

3. Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV

4. Structural studies of vacuolar plasmepsins

5. Critical roles for the digestive vacuole plasmepsins ofPlasmodium falciparumin vacuolar function

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