Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin-Reference-Cited by-同舟云学术

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

Published:2011-05-13 Issue:6031 Volume:332 Page:816-821
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fleishman Sarel J.¹,Whitehead Timothy A.¹,Ekiert Damian C.²,Dreyfus Cyrille²,Corn Jacob E.¹,Strauch Eva-Maria¹,Wilson Ian A.²,Baker David¹³

Affiliation:

1. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

2. Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

3. Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Abstract

Proteins can be designed that bind to specific patches on target proteins to alter their subsequent interactions.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference20 articles.

1. Monoclonal antibodies come of age

2. Manufacturing Immunity to Disease in a Test Tube: The Magic Bullet Realized

3. Computational redesign of protein-protein interaction specificity

4. Computational Design of a PAK1 Binding Protein

5. A de novo designed protein-protein interface

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