Autophagy as a Regulated Pathway of Cellular Degradation-Reference-Cited by-同舟云学术

Autophagy as a Regulated Pathway of Cellular Degradation

Published:2000-12 Issue:5497 Volume:290 Page:1717-1721
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Klionsky Daniel J.¹,Emr Scott D.²

Affiliation:

1. Department of Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109–1048, USA.

2. Division of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, and Howard Hughes Medical Institute, La Jolla, CA 92093–0668, USA.

Abstract

Macroautophagy is a dynamic process involving the rearrangement of subcellular membranes to sequester cytoplasm and organelles for delivery to the lysosome or vacuole where the sequestered cargo is degraded and recycled. This process takes place in all eukaryotic cells. It is highly regulated through the action of various kinases, phosphatases, and guanosine triphosphatases (GTPases). The core protein machinery that is necessary to drive formation and consumption of intermediates in the macroautophagy pathway includes a ubiquitin-like protein conjugation system and a protein complex that directs membrane docking and fusion at the lysosome or vacuole. Macroautophagy plays an important role in developmental processes, human disease, and cellular response to nutrient deprivation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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