Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold-Reference-Cited by-同舟云学术

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

Published:2011-10-21 Issue:6054 Volume:334 Page:373-376
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Azoitei Mihai L.¹,Correia Bruno E.¹²,Ban Yih-En Andrew¹,Carrico Chris¹³,Kalyuzhniy Oleksandr¹,Chen Lei⁴,Schroeter Alexandria¹,Huang Po-Ssu¹,McLellan Jason S.⁴,Kwong Peter D.⁴,Baker David¹⁵,Strong Roland K.³,Schief William R.¹⁶⁷

Affiliation:

1. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

2. Ph.D. Program in Computational Biology, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

3. Divison of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

5. Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

6. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

7. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

A two-segment HIV epitope grafted into a scaffold protein maintains high affinity for a broadly neutralizing antibody.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

1. Computational design of receptor and sensor proteins with novel functions

2. Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

3. Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

4. Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

5. Elicitation of structure-specific antibodies by epitope scaffolds

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