In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

Author:

Radford Elizabeth J.1,Ito Mitsuteru1,Shi Hui1,Corish Jennifer A.1,Yamazawa Kazuki1,Isganaitis Elvira2,Seisenberger Stefanie3,Hore Timothy A.3,Reik Wolf3,Erkek Serap456,Peters Antoine H. F. M.45,Patti Mary-Elizabeth2,Ferguson-Smith Anne C.1

Affiliation:

1. Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.

2. Research Division, Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.

3. The Babraham Institute, Babraham, Cambridge, and Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

4. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

5. Faculty of Sciences, University of Basel, Basel, Switzerland.

6. Swiss Institute of Bioinformatics, Basel, Switzerland.

Abstract

The nutritional sins of the mother… Prenatal exposures of a mother can affect the health of her offspring, but how? Radford et al. found that the male progeny of undernourished pregnant mice had altered DNA chemistry in their sperm. In addition, the offspring displayed compromised metabolic health. The specific affected genes not only lost DNA methylation but also lacked the normal sperm DNA packaging factors (protamines) and instead were enriched in nucleosomes. Thus, when subjected to a suboptimal prenatal environment, offspring feel the effects of the maternal assault. Science , this issue p. 10.1126/science.1255903

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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