Rapid development of a DNA vaccine for Zika virus

Author:

Dowd Kimberly A.1,Ko Sung-Youl2,Morabito Kaitlyn M.2,Yang Eun Sung2,Pelc Rebecca S.1,DeMaso Christina R.1,Castilho Leda R.23,Abbink Peter4,Boyd Michael4,Nityanandam Ramya4,Gordon David N.1,Gallagher John Robert5,Chen Xuejun2,Todd John-Paul2,Tsybovsky Yaroslav6,Harris Audray5,Huang Yan-Jang S.7,Higgs Stephen7,Vanlandingham Dana L.7,Andersen Hanne8,Lewis Mark G.8,De La Barrera Rafael9,Eckels Kenneth H.9,Jarman Richard G.10,Nason Martha C.11,Barouch Dan H.4,Roederer Mario2,Kong Wing-Pui2,Mascola John R.2,Pierson Theodore C.1,Graham Barney S.2

Affiliation:

1. Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. Federal University of Rio de Janeiro, COPPE (Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia), Chemical Engineering Program, Rio de Janeiro, Rio de Janeiro, Brazil.

4. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

5. Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

6. Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

7. Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.

8. Bioqual, Rockville, MD 20852, USA.

9. Translational Medicine Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

10. Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

11. Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.

Abstract

A DNA vaccine candidate for Zika The ongoing Zika epidemic in the Americas and the Caribbean urgently needs a protective vaccine. Two DNA vaccines composed of the genes that encode the structural premembrane and envelope proteins of Zika virus have been tested in monkeys. Dowd et al. show that two doses of vaccine given intramuscularly completely protected 17 of 18 animals against Zika virus challenge. A single low dose of vaccine was not protective but did reduce viral loads. Protection correlated with serum antibody neutralizing activity. Phase I clinical trials testing these vaccines are already ongoing. Science , this issue p. 237

Funder

National Institute of Allergy and Infectious Diseases

Department of Diagnostic Medicine and Pathobiology

Frederick National Laboratory for Cancer Research

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3