Affiliation:
1. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Abstract
Mr. Blebby
Vibrio parahaemolyticus
, an important cause of contaminated fish-associated food poisoning, kills infected host cells within hours, using three sequential mechanisms: autophagy, cell rounding, and cell lysis.
Broberg
et al.
(p.
1660
, published online 19 August) now describe a molecular mechanism of a bacterial effector protein that facilitates cell lysis by disrupting a target involved in regulating membrane dynamics and the actin cytoskeleton. The
Vibrio
effector, VPA0450, causes target cell membrane blebbing. The protein acts as an inositol polyphosphate 5-phosphatase and disrupts cytoskeletal binding sites on the inner surface of the plasma membrane of infected cells by hydrolyzing phosphatidylinositol 4,5-bisphosphate.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
94 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献