A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A-Reference-Cited by-同舟云学术

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

Published:1997-03-14 Issue:5306 Volume:275 Page:1652-1654
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

He Xi¹,Saint-Jeannet Jean-Pierre¹,Wang Yanshu¹,Nathans Jeremy¹,Dawid Igor¹,Varmus Harold¹

Affiliation:

1. X. He and H. Varmus, National Cancer Institute, Building 49, Room 4A56, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains

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3. A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled

4. A new member of the frizzled family from Drosophila functions as a Wingless receptor

5. Wnt genes

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