Synthetic transcription elongation factors license transcription across repressive chromatin-Reference-Cited by-同舟云学术

Synthetic transcription elongation factors license transcription across repressive chromatin

Published:2017-12-22 Issue:6370 Volume:358 Page:1617-1622
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Erwin Graham S.¹,Grieshop Matthew P.¹^ORCID,Ali Asfa¹,Qi Jun²^ORCID,Lawlor Matthew²^ORCID,Kumar Deepak³⁴,Ahmad Istaq³⁴^ORCID,McNally Anna⁵^ORCID,Teider Natalia⁵,Worringer Katie⁵^ORCID,Sivasankaran Rajeev⁵,Syed Deeba N.⁶^ORCID,Eguchi Asuka¹^ORCID,Ashraf Md.¹,Jeffery Justin⁷,Xu Mousheng²,Park Paul M. C.²,Mukhtar Hasan⁶,Srivastava Achal K.³,Faruq Mohammed⁴,Bradner James E.²⁵^ORCID,Ansari Aseem Z.¹⁸^ORCID

Affiliation:

1. Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706, USA.

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

3. Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

4. Genomics and Molecular Medicine, Council of Scientific and Industrial Research (CSIR)–Institute of Genomics and Integrative Biology (IGIB), New Delhi, India.

5. Novartis Institutes for BioMedical Research (NIBR), Cambridge, MA 02139, USA.

6. Department of Dermatology, University of Wisconsin–Madison, Madison, WI 53706, USA.

7. Small Animal Imaging Facility, University of Wisconsin Carbone Cancer Center, Madison, WI 53792, USA.

8. The Genome Center of Wisconsin, University of Wisconsin–Madison, Madison, WI 53706, USA.

Abstract

Chemical control of transcription Friedreich's ataxia, a devastating neurodegenerative disease with no effective therapy, is caused by an expansion of intronic repeats and hence a reduced expression of the FXN gene. Erwin et al. synthesized a molecule that specifically targets the expanded repressive repeats. This molecule thereby licenses productive transcription elongation and restores FXN expression to normal levels. In the future, similar interventions may be effective in a diverse array of diseases caused by unstable expansions in microsatellite repeats. Science , this issue p. 1617

Funder

National Institutes of Health

Indo-US Science and Technology Forum

W.M. Keck Foundation

Hilldale Scholarship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference44 articles.

1. Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers

2. Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans