Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg3293.pdf
Reference98 articles.
1. Lis, J. Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation. Cold Spring Harb. Symp. Quant. Biol. 63, 347–356 (1998).
2. Core, L. J., Waterfall, J. J. & Lis, J. T. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 322, 1845–1848 (2008). GRO-seq maps the position, amount and orientation of transcriptionally engaged RNA polymerases genome-wide and shows peaks of promoter-proximal polymerase residing on ~30% of human genes.
3. Gilchrist, D. A. et al. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell 143, 540–551 (2010). Global analyses of Pol II pausing and nucleosome occupancy reveal that Pol II and nucleosomes compete for promoter occupancy to regulate gene expression coordinately.
4. Lee, C. et al. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Mol. Cell. Biol. 28, 3290–3300 (2008). Comprehensive analysis of promoter-associated Pol II in D. melanogaster using ChIP–chip and permanganate footprinting demonstrates that NELF-mediated pausing of Pol II is common in D. melanogaster.
5. Min, I. M. et al. Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells. Genes Dev. 25, 742–754 (2011).
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