Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics-Reference-Cited by-同舟云学术

Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

Published:2010-10 Issue:6000 Volume:330 Page:86-88
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Arensburger Peter¹,Megy Karine²,Waterhouse Robert M.³⁴,Abrudan Jenica⁵,Amedeo Paolo⁶,Antelo Beatriz⁷,Bartholomay Lyric⁸,Bidwell Shelby⁹,Caler Elisabet⁶,Camara Francisco⁹,Campbell Corey L.¹⁰,Campbell Kathryn S.¹¹,Casola Claudio¹²,Castro Marta T.¹³,Chandramouliswaran Ishwar⁶,Chapman Sinéad B.¹⁴,Christley Scott⁵,Costas Javier¹⁵,Eisenstadt Eric⁶,Feschotte Cedric¹⁶,Fraser-Liggett Claire¹⁷,Guigo Roderic⁹,Haas Brian¹⁴,Hammond Martin²,Hansson Bill S.¹⁸,Hemingway Janet¹⁹,Hill Sharon R.²⁰,Howarth Clint¹⁴,Ignell Rickard²⁰,Kennedy Ryan C.⁵,Kodira Chinnappa D.²¹,Lobo Neil F.⁵,Mao Chunhong²²,Mayhew George²³,Michel Kristin²⁴,Mori Akio⁵,Liu Nannan²⁵,Naveira Horacio²⁶,Nene Vishvanath¹⁷²⁷,Nguyen Nam¹⁶,Pearson Matthew D.¹⁴,Pritham Ellen J.¹⁶,Puiu Daniela²⁸,Qi Yumin²²,Ranson Hilary¹⁹,Ribeiro Jose M. C.²⁹,Roberston Hugh M.³⁰,Severson David W.⁵,Shumway Martin²⁹,Stanke Mario³¹,Strausberg Robert L.⁶,Sun Cheng¹⁶,Sutton Granger⁶,Tu Zhijian (Jake)²²,Tubio Jose Manuel C.⁷,Unger Maria F.⁵,Vanlandingham Dana L.³²,Vilella Albert J.²,White Owen¹⁷,White Jared R.¹⁴,Wondji Charles S.¹⁹,Wortman Jennifer¹⁷,Zdobnov Evgeny M.³⁴³²,Birren Bruce¹⁴,Christensen Bruce M.²³,Collins Frank H.⁵,Cornel Anthony³³,Dimopoulos George³⁴,Hannick Linda I.⁶,Higgs Stephen³²,Lanzaro Gregory C.³⁵,Lawson Daniel²,Lee Norman H.³⁶,Muskavitch Marc A. T.¹⁴³⁷³⁸,Raikhel Alexander S.¹,Atkinson Peter W.¹

Affiliation:

1. Center for Disease Vector Research, University of California Riverside, Riverside, CA 92521, USA.

2. European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

3. University of Geneva Medical School, 1 rue Michel-Servet, 1211 Geneva, Switzerland.

4. Swiss Institute of Bioinformatics, 1 rue Michel-Servet, 1211 Geneva, Switzerland.

5. University of Notre Dame, Notre Dame, IN 46556, USA.

6. J. Craig Venter Institute, Rockville, MD 20850, USA.

7. Complexo Hospitalario Universitario de Santiago, Santiago de Compostela 15706, Spain.

8. Iowa State University, Ames, IA 50011, USA.

9. Center for Genomic Regulation, Universitat Pompeu Fabra, E-08003 Barcelona, Catalonia, Spain.

10. Colorado State University, Fort Collins, CO 80523, USA.

11. Harvard University, Cambridge, MA 02138, USA.

12. Indiana University, Bloomington, IN 47405–3700, USA.

13. Programa d’Epigenética i Biologia del Cáncer, Hospital Duran i Reynals, 08907 Hospitalet de Llobregat, Barcelona, Spain.

14. The Broad Institute, Cambridge, MA 02142, USA.

15. Fundación Pública Galega de Medicina Xenómica–Servizo Galego de Saúde, Santiago de Compostela 15706, Spain.

16. University of Texas Arlington, Arlington, TX 76019, USA.

17. Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

18. Max Planck Institute for Chemical Ecology, 07749 Jena, Germany.

19. Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

20. Swedish University of Agricultural Sciences, 230 53 Alnarp, Sweden.

21. 454 Life Sciences, the Roche Group, Branford, CT 06405, USA.

22. Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

23. University of Wisconsin, Madison, WI 53706, USA.

24. Kansas State University, Manhattan, KS 66506, USA.

25. Auburn University, Auburn, AL 36849, USA.

26. Departamento de Biloxía Celular e Molecular, Universidade da Coruña, 15071 A, Coruña, Spain.

27. International Livestock Research Institute, Nairobi, Kenya.

28. Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA.

29. National Institutes of Health, Bethesda, MD 20892, USA.

30. University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.

31. University of Göttingen, 37077 Göttingen, Germany.

32. Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

33. University of Texas Medical Branch, Galveston, TX 77555, USA.

34. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

35. University of California Davis, Parlier, CA 93648, USA.

36. George Washington University Medical Center, Washington, DC 20037, USA.

37. Boston College, Chestnut Hill, MA 02467, USA.

38. Harvard School of Public Health, Boston, MA 02115, USA.

Abstract

Closing the Vector Circle The genome sequence of Culex quinquefasciatus offers a representative of the third major genus of mosquito disease vectors for comparative analysis. In a major international effort, Arensburger et al. (p. 86 ) uncovered divergences in the C. quinquefasciatus genome compared with the representatives of the other two genera Aedes aegypti and Anopheles gambiae . The main difference noted is the expansion of numbers of genes, particularly for immunity, oxidoreductive functions, and digestive enzymes, which may reflect specific aspects of the Culex life cycle. Bartholomay et al. (p. 88 ) explored infection-response genes in Culex in more depth and uncovered 500 immune response-related genes, similar to the numbers seen in Aedes , but fewer than seen in Anopheles or the fruit fly Drosophila melanogaster . The higher numbers of genes were attributed partly to expansions in those encoding serpins, C-type lectins, and fibrinogen-related proteins, consistent with greater immune surveillance and associated signaling needed to monitor the dangers of breeding in polluted, urbanized environments. Transcriptome analysis confirmed that inoculation with unfamiliar bacteria prompted strong immune responses in Culex . The worm and virus pathogens that the mosquitoes transmit naturally provoked little immune activation, however, suggesting that tolerance has evolved to any damage caused by replication of the pathogens in the insects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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