Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness-Reference-Cited by-同舟云学术

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Published:2015-04-17 Issue:6232 Volume:348 Page:340-343
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Katajisto Pekka¹²³⁴,Döhla Julia⁴,Chaffer Christine L.¹,Pentinmikko Nalle⁴,Marjanovic Nemanja¹²,Iqbal Sharif⁴,Zoncu Roberto¹²³,Chen Walter¹²³,Weinberg Robert A.¹²,Sabatini David M.¹²³⁵⁶

Affiliation:

1. Whitehead Institute for Biomedical Research, Boston, MA 02142, USA.

2. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

3. Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.

4. Institute of Biotechnology, University of Helsinki, P.O. Box 00014, Helsinki, Finland.

5. Broad Institute, Cambridge, MA 02142, USA.

6. The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

Abstract

Stem cells can sort mitochondria by age The renewal of tissues in aging organisms requires stem cells, which have the unusual ability to divide asymmetrically into one daughter cell that retains stem cell properties and another that differentiates into a particular tissue type. Katajisto et al. used photoactivated marker proteins to monitor the age of cell organelles in stemlike cells from human breast tissue and their distribution into daughter cells. Most organelles were evenly distributed, but daughter cells that maintained stem-cell properties received more newly produced mitochondria and fewer old ones. Science , this issue p. 340

Funder

U.S. National Institutes of Health

Howard Hughes Medical Institute

Academy of Finland

Foundations' Post Doc Pool

Juselius Foundation

Marie Curie Actions

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.