Asymmetric Inheritance of Oxidatively Damaged Proteins During Cytokinesis-Reference-Cited by-同舟云学术

Asymmetric Inheritance of Oxidatively Damaged Proteins During Cytokinesis

Published:2003-03-14 Issue:5613 Volume:299 Page:1751-1753
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Aguilaniu Hugo¹²³,Gustafsson Lena²,Rigoulet Michel³,Nyström Thomas¹

Affiliation:

1. Department of Cell and Molecular Biology–Microbiology, Göteborg University, Göteborg, Sweden.

2. Department of Molecular Biotechnology, Chalmers University of Technology, Göteborg, Sweden.

3. Institut de Biochimie et de Génétiques Cellulaires du CNRS, Université Victor Segalen, Bordeaux, France.

Abstract

Carbonylated proteins were visualized in single cells of the budding yeast Saccharomyces cerevisiae , revealing that they accumulate with replicative age. Furthermore, carbonylated proteins were not inherited by daughter cells during cytokinesis. Mother cells of a yeast strain lacking the sir2 gene, a life-span determinant, failed to retain oxidatively damaged proteins during cytokinesis. These findings suggest that a genetically determined, Sir2p-dependent asymmetric inheritance of oxidatively damaged proteins may contribute to free-radical defense and the fitness of newborn cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference17 articles.

1. Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division.

2. Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

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4. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

5. A Mutation in the ATP2 Gene Abrogates the Age Asymmetry Between Mother and Daughter Cells of the Yeast Saccharomyces cerevisiae

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