Spatiotemporal immune zonation of the human kidney-Reference-Cited by-同舟云学术

Spatiotemporal immune zonation of the human kidney

Published:2019-09-27 Issue:6460 Volume:365 Page:1461-1466
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Stewart Benjamin J.¹²³^ORCID,Ferdinand John R.¹^ORCID,Young Matthew D.³^ORCID,Mitchell Thomas J.²³⁴^ORCID,Loudon Kevin W.¹²^ORCID,Riding Alexandra M.¹²^ORCID,Richoz Nathan¹,Frazer Gordon L.¹,Staniforth Joy U. L.¹^ORCID,Vieira Braga Felipe A.³^ORCID,Botting Rachel A.⁵^ORCID,Popescu Dorin-Mirel⁵,Vento-Tormo Roser³,Stephenson Emily⁵^ORCID,Cagan Alex³^ORCID,Farndon Sarah J.³⁶⁷^ORCID,Polanski Krzysztof³^ORCID,Efremova Mirjana³,Green Kile⁵,Del Castillo Velasco-Herrera Martin³^ORCID,Guzzo Charlotte³^ORCID,Collord Grace²³⁸^ORCID,Mamanova Lira³^ORCID,Aho Tevita²^ORCID,Armitage James N.²,Riddick Antony C. P.²,Mushtaq Imran⁶^ORCID,Farrell Stephen²,Rampling Dyanne⁶,Nicholson James²⁸,Filby Andrew⁵,Burge Johanna²,Lisgo Steven⁹^ORCID,Lindsay Susan⁹^ORCID,Bajenoff Marc¹⁰,Warren Anne Y.²,Stewart Grant D.²⁴^ORCID,Sebire Neil⁶⁷,Coleman Nicholas²¹¹,Haniffa Muzlifah³⁵¹²^ORCID,Teichmann Sarah A.³¹³^ORCID,Behjati Sam²³⁸^ORCID,Clatworthy Menna R.¹²³^ORCID

Affiliation:

1. Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.

2. Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.

3. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.

4. Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.

5. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

6. Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.

7. UCL Great Ormond Street Hospital Institute of Child Health, London WC1N 1E, UK.

8. Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

9. Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.

10. Centre d’Immunologie de Marseille-Luminy, 13009 Marseille, France.

11. Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.

12. Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.

13. Theory of Condensed Matter Group, Cavendish Laboratory–Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.

Abstract

Immune landscape of the human kidney Single-cell RNA sequencing has begun to shed light on the full cellular diversity of specific organs. However, these studies rarely examine organ-specific immune cells. Stewart et al. sequenced healthy adult and fetal kidney samples at a single-cell level to define the heterogeneity in epithelial, myeloid, and lymphoid cells. From this dataset, they identified zonation of cells, with relevance to disease and the varied perturbations that occur in different tumor settings. This profiling of the human kidney generates a comprehensive census of existing cell populations that will help inform the diagnosis and treatment of kidney-related diseases. Science , this issue p. 1461

Funder

European Molecular Biology Organization

Wellcome

Lister Institute of Preventive Medicine

Medical Research Council

National Institute for Health Research

Arthritis Research UK

Kidney Research UK

Human Frontier Science Program

Cancer Research UK

CHILDREN with CANCER UK

St Baldrick's Foundation